Notch-associated lncRNAs profiling circuiting epigenetic modification in colorectal cancer
Emam, Omnia; Wasfey, Eman F; Prof. Hamdy, Nadia M.;
Abstract
Colorectal cancer (CRC) is one of the most prevalent digestive cancers, ranking the 2nd cause of cancer-related fatality worldwide. The worldwide burden of CRC is predicted to rise by 60% by 2030. Environmental factors drive, first, inflammation and hence, cancer incidence increase. MAIN: The Notch-signaling system is an evolutionarily conserved cascade, has role in the biological normal developmental processes as well as malignancies. Long non-coding RNAs (LncRNAs) have become major contributors in the advancement of cancer by serving as signal pathways regulators. They can control gene expression through post-translational changes, interactions with micro-RNAs or down-stream effector proteins. Recent emerging evidence has emphasized the role of lncRNAs in controlling Notch-signaling activity, regulating development of several cancers including CRC.
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| Title | Notch-associated lncRNAs profiling circuiting epigenetic modification in colorectal cancer | Authors | Emam, Omnia; Wasfey, Eman F; Prof. Hamdy, Nadia M. | Keywords | Colorectal cancer; Epigenetics; Hallmarks of cancer; Inflammation; Micro-RNAs; Notch; lncRNAs | Issue Date | 13-Oct-2022 | Journal | Cancer cell international | ISSN | 1475-2867 | DOI | 10.1186/s12935-022-02736-2 | PubMed ID | 36229883 | Scopus ID | 2-s2.0-85139845653 |
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