Interactome battling of lncRNA CCDC144NL-AS1: Its role in the emergence and ferocity of cancer and beyond
Abd El Fattah, Yasmine K; Abulsoud, Ahmed I; AbdelHamid, Sherihan G; Prof. Hamdy, Nadia M.;
Abstract
Long non-coding RNAs (lncRNAs) were, once, viewed as "noise" for transcription. Recently, many lncRNAs are functionally linked to several human disorders, including cancer. Coiled-Coil Domain Containing 144 N-Terminal-Like antisense1 (CCDC144NL-AS1) is a newly discovered cytosolic lncRNA. Aberrant CCDC144NL-AS1 expression was discovered in hepatocellular carcinoma (HCC), ovarian cancer (OC), gastric cancer (GC), non-small cell lung cancer (NSCLC), and osteosarcoma. CCDC144NL-AS1 could be a promising prognostic biological marker and therapeutic target for cancer. In this review, we will collect and highlight the available information about CCDC144NL-AS1 role in various cancers. Moreover, we will discuss the diagnostic and prognostic utility of CCDC144NL-AS1 as a new molecular biomarker for several human malignancies, besides its potential therapeutic importance.
Other data
| Title | Interactome battling of lncRNA CCDC144NL-AS1: Its role in the emergence and ferocity of cancer and beyond | Authors | Abd El Fattah, Yasmine K; Abulsoud, Ahmed I; AbdelHamid, Sherihan G; Prof. Hamdy, Nadia M. | Keywords | CCDC144NL-AS1; Epigenetics; Non-coding RNA; cancer hallmarks; microRNA | Issue Date | 1-Dec-2022 | Journal | International journal of biological macromolecules | ISSN | 01418130 | DOI | 10.1016/j.ijbiomac.2022.09.209 | PubMed ID | 36179873 | Scopus ID | 2-s2.0-85139722359 |
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