High-dose methotrexate in Egyptian pediatric acute lymphoblastic leukemia: the impact of ABCG2 C421A genetic polymorphism on plasma levels, what is next?
El Mesallamy, Hala O; Rashed, Wafaa M; Prof. Hamdy, Nadia M.; Hamdy, Nayera;
Abstract
High-dose methotrexate (HD-MTX) is a cornerstone antineoplastic drug in most treatment protocols of pediatric acute lymphoblastic leukemia (ALL). Among the membrane efflux transporters of MTX, the human breast cancer resistant protein is the second member of the G subfamily of ATP-binding cassette (ABC) efflux pump (ABCG2). A single-nucleotide polymorphism (SNP) in ABCG2, the exchange of C to A at position 421, represents 13 % in the Middle Eastern population. We studied the effect of this SNP on the plasma levels of HD-MTX in Egyptian pediatric ALL.
Other data
| Title | High-dose methotrexate in Egyptian pediatric acute lymphoblastic leukemia: the impact of ABCG2 C421A genetic polymorphism on plasma levels, what is next? | Authors | El Mesallamy, Hala O; Rashed, Wafaa M; Prof. Hamdy, Nadia M. ; Hamdy, Nayera | Keywords | ABCG2 C421A genetic polymorphism;Egyptian pediatric acute;Plasma level;High-dose methotrexate | Issue Date | Aug-2014 | Journal | Journal of cancer research and clinical oncology | Volume | 104 | Start page | 1359 | End page | 1365 | ISSN | 01715216 | DOI | 10.1007/s00432-014-1670-y | PubMed ID | 24718721 | Scopus ID | 2-s2.0-84904354217 |
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