Cytotoxic activity and molecular docking of a novel biflavonoid isolated from Jacaranda acutifolia (Bignoniaceae)
Mostafa, Nada M; Ashour, Mohamed L.; Eldahshan, Omayma;
Abstract
A novel biflavonoid [kaempferol (6→8″) apigenin] was isolated from the leaves of Jacaranda acutifolia. The structure was elucidated based on chemical evidence, 1D and 2D spectroscopic analyses as well as spectrometric techniques. The compound showed promising cytotoxic activity against breast cancer cell line MCF-7. The anticancer activity was explained via virtual docking of the isolated compound to the main sites in the human cyclin-dependent kinase2 (CDK2) crystal structure.
Other data
| Title | Cytotoxic activity and molecular docking of a novel biflavonoid isolated from Jacaranda acutifolia (Bignoniaceae) | Authors | Mostafa, Nada M; Ashour, Mohamed L. ; Eldahshan, Omayma | Keywords | Bignoniaceae;Jacaranda acutifolia;biflavonoid;cytotoxic activity;molecular docking | Issue Date | Sep-2016 | Journal | Natural Product Research | Volume | 30 | Issue | 18 | Start page | 2093 | End page | 2100 | ISSN | 1478-6419 1478-6427 |
DOI | 10.1080/14786419.2015.1114938 | PubMed ID | 26594904 |
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