Intranasally administered melatonin core-shell polymeric nanocapsules: A promising treatment modality for cerebral ischemia
Bseiso, Eman A; Abd El-Aal, Sarah A; Nasr, Maha; Sammour, Omaima; Abd El Gawad, Nabaweya A;
Abstract
The neurohormone melatonin (MEL) has been reported as a promising neuroprotective molecule, however it suffers pharmaceutical limitations such as poor solubility and low bioavailability, which hinder its pharmacological and clinical potential. In the current work, MEL was loaded in core-shell nanocarrier system; polymeric nanocapsules (PNCs), and assessed for its potential in cerebral ischemia reperfusion injury rat model when administered intranasally.
Other data
| Title | Intranasally administered melatonin core-shell polymeric nanocapsules: A promising treatment modality for cerebral ischemia | Authors | Bseiso, Eman A; Abd El-Aal, Sarah A; Nasr, Maha ; Sammour, Omaima ; Abd El Gawad, Nabaweya A | Keywords | Brain ischemia; Cerebral ischemia reperfusion; D-optimal design; Intranasal delivery; Melatonin; Neuroprotective; Polymeric nanocapsules | Issue Date | 1-Oct-2022 | Journal | Life sciences | DOI | 10.1016/j.lfs.2022.120797 | PubMed ID | 35841976 |
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