Nanoparticles Based on Linear and Star-Shaped Poly(Ethylene Glycol)-Poly(ε-Caprolactone) Copolymers for the Delivery of Antitubulin Drug
Shalaby, Karim S; Soliman, Mahmoud E; Bonacucina, Giulia; Cespi, Marco; Palmieri, Giovanni F; Sammour, Omaima A; El Shamy, Abdelhameed A; Illum, Lisbeth; Casettari, Luca;
Abstract
Biodegradable polymeric nanoparticles of different architectures based on polyethylene glycol-co-poly(ε-caprolactone) block copolymers have been loaded with noscapine (NOS) to study their effect on its anticancer activity. It was intended to use solubility of NOS in an acidic environment and ability of the nanoparticles to passively target drugs into cancer tissue to modify the NOS pharmacokinetic properties and reduce the requirement for frequent injections.
Other data
| Title | Nanoparticles Based on Linear and Star-Shaped Poly(Ethylene Glycol)-Poly(ε-Caprolactone) Copolymers for the Delivery of Antitubulin Drug | Authors | Shalaby, Karim S; Soliman, Mahmoud E; Bonacucina, Giulia; Cespi, Marco; Palmieri, Giovanni F; Sammour, Omaima A ; El Shamy, Abdelhameed A; Illum, Lisbeth; Casettari, Luca | Keywords | noscapine; pH dependent release; passive targeting; polyethylene glycol-co-poly(ε-caprolactone) (PEG-co-PCL); polymeric nanoparticles | Issue Date | Aug-2016 | Journal | Pharmaceutical research | DOI | 10.1007/s11095-016-1939-8 | PubMed ID | 27177721 |
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