Collaborative role of calcitriol with buparlisib in the tongue squamous cell carcinoma cell line by modulating the Casp3 and Akt1 gene expression
Helmy, Iman; Shamaa, Karma; Ahmed, Basma Abdelrahman;
Abstract
Oral squamous cell carcinoma (OSCC) is a devastating disease with an increasing incidence. Among the commonly dysregulated pathways in oncogenesis are the phosphatidylinositol 3-kinase / protein kinase-B/ mammalian target of rapamycin (PI3K/AKT/mTOR) and apoptotic pathways. Buparlisib, a pan-class I PI3K inhibitor, has antineoplastic effects, but its associated toxicities hinder its beneficial role in patients. Calcitriol, active vitamin D (Vit D), possesses anticancer functions by targeting both pathways. Therefore, Vit D could help achieve low buparlisib doses and boost its effects.
Other data
| Title | Collaborative role of calcitriol with buparlisib in the tongue squamous cell carcinoma cell line by modulating the Casp3 and Akt1 gene expression | Authors | Helmy, Iman ; Shamaa, Karma ; Ahmed, Basma Abdelrahman | Keywords | AKT1 protein; BKM120; caspase-3; oral tongue squamous cell carcinoma; vitamin D | Issue Date | Oct-2025 | Journal | Dental and Medical problems | Volume | 62 | Issue | 5 | Start page | 891 | End page | 898 | ISSN | 1644387X | DOI | https://doi.org/10.17219/dmp/175583 | PubMed ID | 41243960 | Scopus ID | 2-s2.0-105022234885 |
Attached Files
| File | Description | Size | Format | Existing users please Login |
|---|---|---|---|---|
| Pubarlisib and Vit D Article.pdf | 907.81 kB | Adobe PDF | Request a copy | |
| Collaborative role of calcitriol with buparlisib in the tongue squamous cell .pdf | 907.81 kB | Unknown | Request a copy |
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