Phage therapeutic delivery methods and clinical trials for combating clinically relevant pathogens
Selim, Heba Mohammed Refat M; Gomaa, Fatma Alzahraa M; Alshahrani, Mohammad Y; Morgan, Radwa N; Aboshanab, Khaled;
Abstract
The ongoing global health crisis caused by multidrug-resistant (MDR) bacteria necessitates quick interventions to introduce new management strategies for MDR-associated infections and antimicrobial agents' resistance. Phage therapy emerges as an antibiotic substitute for its high specificity, efficacy, and safety profiles in treating MDR-associated infections. Various in vitro and in vivo studies denoted their eminent bactericidal and anti-biofilm potential. This review addresses the latest developments in phage therapy regarding their attack strategies, formulations, and administration routes. It additionally discusses and elaborates on the status of phage therapy undergoing clinical trials, and the challenges encountered in their usage, and explores prospects in phage therapy research and application.
Other data
| Title | Phage therapeutic delivery methods and clinical trials for combating clinically relevant pathogens | Authors | Selim, Heba Mohammed Refat M; Gomaa, Fatma Alzahraa M; Alshahrani, Mohammad Y; Morgan, Radwa N; Aboshanab, Khaled | Keywords | Phage therapy; antibiotics; bacteriophages; multidrug-resistant; phage cocktail | Issue Date | Mar-2025 | Journal | Therapeutic delivery | ISSN | 2041-5990 2041-6008 |
DOI | 10.1080/20415990.2024.2426824 | PubMed ID | 39545771 | Scopus ID | 2-s2.0-85213336751 |
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