In vitro and preclinical evaluation of the antifungal activity of 6-methoxy-1 H-indole-2-carboxylic acid produced by Bacillus toyonensis strain OQ071612 formulated as nanosponge hydrogel
El-Sayed, Sayed E; Abdelaziz, Neveen A; El-Housseiny, Ghadir S; Aboshanab, Khaled;
Abstract
In a previous study, 6-methoxy-1 H-indole-2-carboxylic acid (MICA) was isolated from the culture broth of Bacillus toyonensis strain OQ071612 soil isolate in our laboratory, and it demonstrated promising antifungal activities. The current study was designed to create a nanosponge (NS)-hydrogel (HG)-containing MICA followed by in vitro and preclinical evaluation for potential clinical use in the topical treatment of mycotic infections.
Other data
| Title | In vitro and preclinical evaluation of the antifungal activity of 6-methoxy-1 H-indole-2-carboxylic acid produced by Bacillus toyonensis strain OQ071612 formulated as nanosponge hydrogel | Authors | El-Sayed, Sayed E; Abdelaziz, Neveen A; El-Housseiny, Ghadir S; Aboshanab, Khaled | Keywords | Bacillus toyonensis; Antifungal; Box Behnken design; Hydrogel; Nanosponges | Issue Date | 1-Apr-2025 | Journal | Microbial Cell Factories | ISSN | 1475-2859 | DOI | 10.1186/s12934-025-02688-y | PubMed ID | 40169999 | Scopus ID | 2-s2.0-105001531687 |
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