D-optimal design model and biosynthetic pathway for gentamicin production by Micromonospora purpureochromogenes NRRL B-16094

Suliman, Muath; Bishr, Amr S; Tohamy, Sally T K; Alshahrani, Mohammad Y; Aboshanab, Khaled;

Abstract


Micromonospora purpureochromogenes NRRL B-16094, a natural producer of gentamicin (GEN), a 5,6-diglycosylated 2-dexoystreptamine-aminoglycoside antibiotic (2DOS-AGA) broad-spectrum bactericidal activity. In literature, limited studies are concerned with the biosynthetic route and various cultural conditions influencing GEN production.


Other data

Title D-optimal design model and biosynthetic pathway for gentamicin production by Micromonospora purpureochromogenes NRRL B-16094
Authors Suliman, Muath; Bishr, Amr S; Tohamy, Sally T K; Alshahrani, Mohammad Y; Aboshanab, Khaled 
Keywords D-optimal design Micromonospora purpureochromogenes NRRL B-16094; Fortimicin; Gentamicin; Kanamycin
Issue Date 20-May-2025
Journal BMC microbiology 
ISSN 1471-2180
DOI 10.1186/s12866-025-04001-8
PubMed ID 40394500
Scopus ID 2-s2.0-105005553092

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