Synthesis of Some Novel Indoline-2,3-Dione Derivatives and the Influence of Gamma Irradiation on Their Biological Activities
Abass, Eman; Taher, H. A.; El-Farargy, A. F.; Elewa, Safaa I.;
Abstract
2-(2-oxoindolin-3-ylidene)-N-phenylhydrazinecarbothioamide (4) was synthesized by reaction of 3-hydrazonoindolin-2-one (3) with phenyl isothiocyanate in DMF in presence of potassium hydroxide. Thus, treatment of 4 with the appropriate halo ketones, hydrazonoyl halides, and benzylidene malononitriles afforded thiazolidin-4-one, and thiadiazole derivatives. Moreover, structures of the newly synthesized compounds were elucidated as based of elemental analysis and spectral data. Also, the influence of gamma irradiation on the biological activities of the new compounds was evaluated.
Other data
| Title | Synthesis of Some Novel Indoline-2,3-Dione Derivatives and the Influence of Gamma Irradiation on Their Biological Activities | Authors | Abass, Eman ; Taher, H. A.; El-Farargy, A. F.; Elewa, Safaa I. | Keywords | antimicrobial activity | gamma radiation | hydrazonylhalides | Indoline-2,3-dione | phenylisothiocyanate | thiazoles | Issue Date | 1-Jan-2022 | Journal | POLYCYCLIC AROMATIC COMPOUNDS | ISSN | 10406638 | DOI | 10.1080/10406638.2021.1991395 | Scopus ID | 2-s2.0-85118154039 |
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