Liraglutide improves depressive and cognitive deficits in a high-fat diet rat model of obesity: the role of hippocampal autophagy and the PI3K/Akt/mTOR pathway
Magdy, Yosra M; Kamar, Sherif A; Habib, Mohamed Z.; Rady, Hagar Yousry; Rabei, Mohammed R; Khedr, Sara;
Abstract
Psychiatric disorders are a largely elusive aspect of obesity, representing a growing public health concern. In this regard, a large body of evidence indicates a pivotal role of disturbed autophagic flux in the pathogenesis of obesity-associated neuropsychiatric deficits.
Other data
| Title | Liraglutide improves depressive and cognitive deficits in a high-fat diet rat model of obesity: the role of hippocampal autophagy and the PI3K/Akt/mTOR pathway | Authors | Magdy, Yosra M; Kamar, Sherif A; Habib, Mohamed Z. ; Rady, Hagar Yousry; Rabei, Mohammed R; Khedr, Sara | Keywords | Autophagy; Cognitive dysfunction; Depression; High-fat diet; Hippocampus; Liraglutide | Issue Date | Dec-2025 | Journal | Psychopharmacology | ISSN | 0033-3158 1432-2072 |
DOI | 10.1007/s00213-025-06834-7 | PubMed ID | 40526304 |
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| s00213-025-06834-7.pdf | 3.31 MB | Adobe PDF | Request a copy |
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