Effect of Nano-Selenium on Oxidative Stress Induced by Thioacetamide in albino rats

Abstract

The conducted study was aimed to evaluate effect of selenium nanoparticles (SeNPs) on biochemical parameters, liver toxicity and renal failure induced by Thioacetamide (TAA) in male albino rats. In the present study the experimental rats were divided into 4 groups (6 rats/group) as follows: Group 1: Normal control (NC), only treated with 0.9% saline solution, group 2: treated with SeNPs (0.5mg/Kg body weight), group 3: treated with TAA [100 mg/Kg body weight], group 4: treated with the same dose of TAA + SeNPs as in group 2 & 3. The experiment was continued for three months, and blood samples were taken for analysis every month. The results indicate that TAA causes significant alterations in biochemical parameters. Besides, TAA-induces hepatic fibrosis and histological manner of liver and elevates serum levels of aminotransferases, increases oxidative stress as malondialdehyde (MDA) biomarker of lipid peroxidation. Also, TAA significantly decreases levels of antioxidants enzyme activities e.g. superoxide dismutase (SOD), glutathione reductase (GR), catalase (CAT) and reduced glutathione (GSH). While administration of SeNPs enhances liver enzymes and reduces the oxidative stress. In addition, data obtained reveal that SeNPs significantly reduce the harmful effect of TAA in rats. It could be concluded that SeNPs has powerful as antioxidant and hepato-protective effects. However nano selenium plays as antagonistic agent against toxicity induced by thioacetamide.