Underrepresentation of Arabs in Functional Genetics Studies: Opportunities and Obstacles for Advancing Biology and Human Health

Abstract

A significant challenge to the transnational application of genetics and functional genomic studies is the underrepresentation of certain populations. In this work, we emphasise that while there are over 500 million Arabs living across 22 countries, they are largely underrepresented in genetic studies. Remarkably, only 0.96% of the Genome-Wide Association Studies (GWAS) include Arab participants. This trend is also apparent in various other genetic databases, which not only limit biological discoveries but also exacerbate health inequity. To address this urgent issue, we propose a comprehensive roadmap aimed at effectively integrating the Arab population into genomic research. This strategy includes creating regional genetic biobanks and establishing advanced research programs in translational functional genomics, as well as fostering greater collaboration. Ultimately, this approach will pave the way for more effective precision medicine and health equity for the Arab population and beyond.