CONVENIENT ONE-POT SYNTHESIS OF CHROMONE DERIVATIVES AND THEIR ANTIFUNGAL AND ANTIBACTERIAL EVALUATION
Sherif B. Abdel Ghani;
Abstract
A one-pot method for the synthesis of chromone derivatives from the reaction of
2-hydroxyacetophenones with aliphatic or aromatic acid chlorides is reported. Esterifica
tion and Baker–Venkataraman rearrangement were promoted by t-BuOK, which was
followed directly by acid-catalyzed cyclization in one pot. Some of 2-cyclohexyl- and
2-cyclohexylmethyl-substituted chromones displayed activity against plant pathogenic
fungal strains.
Supplemental materials are available for this article. Go to the publisher’s online edition
of Synthetic Communications1 to view the free supplemental file.
2-hydroxyacetophenones with aliphatic or aromatic acid chlorides is reported. Esterifica
tion and Baker–Venkataraman rearrangement were promoted by t-BuOK, which was
followed directly by acid-catalyzed cyclization in one pot. Some of 2-cyclohexyl- and
2-cyclohexylmethyl-substituted chromones displayed activity against plant pathogenic
fungal strains.
Supplemental materials are available for this article. Go to the publisher’s online edition
of Synthetic Communications1 to view the free supplemental file.
Other data
| Title | CONVENIENT ONE-POT SYNTHESIS OF CHROMONE DERIVATIVES AND THEIR ANTIFUNGAL AND ANTIBACTERIAL EVALUATION | Authors | Sherif B. Abdel Ghani | Keywords | Antifungal activity; chromones; flavonoids; heterocycles | Issue Date | 2013 | Publisher | Taylor & Francis Group, LLC | Volume | 43 | Start page | 1549 | End page | 1556 | DOI | DOI: 10.1080/00397911.2011.647222 |
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