Re-purposed phenobarbital-loaded squarticles: A novel approach for the topical management of chemotherapy-induced alopecia
Fereig, Salma A; Youshia, John; M. El Zaafarany, Ghada; Arafa, Mona G; Abdel-Mottaleb, Mona;
Abstract
Chemotherapy-induced alopecia (CIA) causes significant psychological distress, prompting the need for effective prophylactic or therapeutic interventions. Phenobarbital, a potential agent for re-purposing towards CIA prophylaxis and/or treatment, activates ABC receptors to expel chemotherapeutic agents from hair follicles. Squarticles, nanostructured lipid carriers enriched with squalene, are emerging nanocarriers that selectively target hair follicles via interaction with physiological sebum.
Other data
| Title | Re-purposed phenobarbital-loaded squarticles: A novel approach for the topical management of chemotherapy-induced alopecia | Authors | Fereig, Salma A; Youshia, John ; M. El Zaafarany, Ghada ; Arafa, Mona G; Abdel-Mottaleb, Mona | Keywords | Chemotherapy-induced alopecia; Drug re-purposing; Hair follicle targeting, phenobarbital; Nanostructured lipid carriers; Squarticles | Issue Date | Apr-2026 | Journal | European journal of pharmaceutics and biopharmaceutics | Volume | 221 | ISSN | 09396411 | DOI | 10.1016/j.ejpb.2026.115005 | PubMed ID | 41587585 | Scopus ID | 2-s2.0-105028516172 |
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