Effect of APOE4 Allele and Gender on the Rate of Atrophy in the Hippocampus, Entorhinal Cortex, and Fusiform Gyrus in Alzheimer's Disease
Hamza, Eid Abo; Moustafa, Ahmed A; Tindle, Richard; Karki, Rasu; Nalla, Shahed; Hamid, Mohamed S.; El Haj, Mohamad;
Abstract
The hippocampus, entorhinal cortex, and fusiform gyrus are brain areas that deteriorate during early-stage Alzheimer's disease (AD). The ApoE4 allele has been identified as a risk factor for AD development, is linked to an increase in the aggregation of amyloid ß (Aß) plaques in the brain, and is responsible for atrophy of the hippocampal area. However, to our knowledge, the rate of deterioration over time in individuals with AD, with or without the ApoE4 allele, has not been investigated.
Other data
| Title | Effect of APOE4 Allele and Gender on the Rate of Atrophy in the Hippocampus, Entorhinal Cortex, and Fusiform Gyrus in Alzheimer's Disease | Authors | Hamza, Eid Abo; Moustafa, Ahmed A; Tindle, Richard; Karki, Rasu; Nalla, Shahed; Hamid, Mohamed S. ; El Haj, Mohamad | Keywords | APOE gene; Alzheimer’s disease; disease progression; entorhinal cortex; fusiform gyrus; gender difference; hippocampus | Issue Date | 9-Mar-2023 | Journal | Current Alzheimer research | ISSN | 15672050 | DOI | 10.2174/1567205020666230309113749 | PubMed ID | 36892120 | Scopus ID | 2-s2.0-85151919087 |
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