Nose to brain delivery of naringin-loaded chitosan nanoparticles for potential use in oxaliplatin-induced chemobrain in rats: impact on oxidative stress, cGAS/STING and HMGB1/RAGE/TLR2/MYD88 inflammatory axes
Hanna, Diana M.F.; Youshia, John; Fahmy, Sarah Farid; George, Mina Y.;
Abstract
Oxaliplatin induces chemobrain in cancer patients/survivors. Nutraceutical naringin has antioxidant and anti-inflammatory properties with low oral bioavailability. Our aim was to formulate naringin in chitosan nanoparticles for nose to brain delivery and assess its neuroprotective effect against oxaliplatin-induced chemobrain in rats.
Other data
| Title | Nose to brain delivery of naringin-loaded chitosan nanoparticles for potential use in oxaliplatin-induced chemobrain in rats: impact on oxidative stress, cGAS/STING and HMGB1/RAGE/TLR2/MYD88 inflammatory axes | Authors | Hanna, Diana M.F. ; Youshia, John ; Fahmy, Sarah Farid; George, Mina Y. | Keywords | Chemobrain; Chitosan nanoparticles; Naringin; Nose to brain delivery; Oxaliplatin; cGAS/STING | Issue Date | 2023 | Journal | Expert opinion on drug delivery | ISSN | 17425247 | DOI | 10.1080/17425247.2023.2228685 | PubMed ID | 37357778 | Scopus ID | 2-s2.0-85163634287 |
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