Roflumilast attenuates doxorubicin and cyclophosphamide combination-induced chemobrain in rats through modulation of NLRP3/ASC/caspase-1/GSDMD axis
Eskander, Georgette; Abdelhamid, Sherihan G; Wahdan, Sara A; Radwan, Sara;
Abstract
The aim of this study is to investigate the neuroprotective effect of roflumilast, a phosphodiesterase-4 (PDE-4) inhibitor on cognitive impairment induced by doxorubicin (DOX)/cyclophosphamide (CP) combination therapy and to elucidate its modulatory effect on the pyroptosis pathway.
Other data
| Title | Roflumilast attenuates doxorubicin and cyclophosphamide combination-induced chemobrain in rats through modulation of NLRP3/ASC/caspase-1/GSDMD axis | Authors | Eskander, Georgette; Abdelhamid, Sherihan G; Wahdan, Sara A; Radwan, Sara | Keywords | Chemobrain; Cyclophosphamide and doxorubicin; GSDMD; NLRP3; Pyroptosis; Roflumilast | Issue Date | 1-Feb-2025 | Journal | Life sciences | ISSN | 00243205 | DOI | 10.1016/j.lfs.2025.123378 | PubMed ID | 39788415 | Scopus ID | 2-s2.0-85214321276 |
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