Optimized Moxifloxacin Nanoliposomes with Enhanced Stability
Hamed, Amira; Osman, Rihab; samar mansour;
Abstract
Nanoliposomes (NLs) prepared by three different methods were
compared in terms of their ability to encapsulate moxifloxacin
hydrochloride (MXF). Formulation parameters namely,
phospholipid to cholesterol ratio, drug to lipid ratio, and pH,
were optimized. NLs with size 277.07±2.18nm and entrapment
efficiency (EE) of 66.25±1.89% were obtained. The stability of
MXF-NLs was enhanced by lyophilization using different ratios
of trehalose. Lyophilization with lipid/trehalose ratio 1:6 was
the best ratio in terms of size and EE obtained after rehydration
of NLs.
compared in terms of their ability to encapsulate moxifloxacin
hydrochloride (MXF). Formulation parameters namely,
phospholipid to cholesterol ratio, drug to lipid ratio, and pH,
were optimized. NLs with size 277.07±2.18nm and entrapment
efficiency (EE) of 66.25±1.89% were obtained. The stability of
MXF-NLs was enhanced by lyophilization using different ratios
of trehalose. Lyophilization with lipid/trehalose ratio 1:6 was
the best ratio in terms of size and EE obtained after rehydration
of NLs.
Other data
| Title | Optimized Moxifloxacin Nanoliposomes with Enhanced Stability | Authors | Hamed, Amira ; Osman, Rihab ; samar mansour | Keywords | Nanoliposomes; Moxifloxacin hydrochloride; Lyophilization; Stability | Issue Date | 2-May-2016 | Publisher | Human Journals ( international journal of pharmacy and pharmaceutical research) | Journal | international journal of pharmacy and pharmaceutical research) | Volume | 6 | Issue | 2 | Start page | 148 | End page | 169 |
Attached Files
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