Hermansones A and B: Bioactive naphthazarin congeners from the European crust fungus Hermanssonia centrifuga
Sum, Winnie Chemutai; Ebada, Sherif S; Muema, Jackson M; Kellner, Harald; Mándi, Attila; Kurtán, Tibor; Stadler, Marc; Ebada, Sherif;
Abstract
Two previously undescribed naphthazarins named hermansones A (1) and B (2), were isolated from the wood-decaying basidiomycete Hermanssonia centrifuga. The study presents the first report of natural products from the species. The structures of the secondary metabolites were elucidated through NMR spectroscopy and mass spectrometry. The absolute configuration of compound 1 was elucidated using TDDFT-ECD calculations. Hermansone B (2) demonstrated moderate inhibitory effects against Chikungunya virus at IC50 of 55.97 μM, without inducing notable cytotoxicity.
Other data
| Title | Hermansones A and B: Bioactive naphthazarin congeners from the European crust fungus Hermanssonia centrifuga | Authors | Sum, Winnie Chemutai; Ebada, Sherif S; Muema, Jackson M; Kellner, Harald; Mándi, Attila; Kurtán, Tibor; Stadler, Marc; Ebada, Sherif | Keywords | Antiviral;Boryquinone;Hermanssonia;Meruliaceae;Naphthoquinone | Issue Date | Dec-2024 | Publisher | Elsevier | Journal | Fitoterapia | Volume | 179 | Start page | 106261 | ISSN | 0367326X | DOI | 10.1016/j.fitote.2024.106261 | PubMed ID | 39419124 | Scopus ID | 2-s2.0-85207745943 |
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