Laburnicolamine: A Rare Penillic Acid Congener from the Nematode Cyst-Associated Fungus Laburnicola nematophila
Wennrich, Jan-Peer; Holzenkamp, Caren; Ashrafi, Samad; Maier, Wolfgang; Wang, Hao; Ibrahim, Mahmoud A A; Stadler, Marc; Ebada, Sherif;
Abstract
A chemical investigation of a methanol extract derived from a solid-state rice culture of the nematode-cyst associated fungus Laburnicola nematophila K01 led to the isolation and characterization of a previously undescribed penillic acid analogue named laburnicolamine (1). The chemical structure was elucidated through comprehensive 1D and 2D NMR spectroscopic analyses in methanol-d4 and DMSO-d6, alongside with HR-ESI-MS spectrometry. The absolute configuration of 1 was concluded through the electronic circular dichroism (ECD) and time-dependent density functional theory-ECD (TDDFT-ECD) computations compared to its acquired spectrum. Biological assays revealed that compound 1 exhibited no significant cytotoxic, antimicrobial, or nematicidal activity.
Other data
| Title | Laburnicolamine: A Rare Penillic Acid Congener from the Nematode Cyst-Associated Fungus Laburnicola nematophila | Authors | Wennrich, Jan-Peer; Holzenkamp, Caren; Ashrafi, Samad; Maier, Wolfgang; Wang, Hao; Ibrahim, Mahmoud A A; Stadler, Marc; Ebada, Sherif | Keywords | Laburnicola;antimicrobial;penicillin G;penillic acid | Issue Date | Aug-2024 | Publisher | Wiley | Journal | Chemistry & Biodiversity | Volume | 21 | Issue | 8 | Start page | e202401152 | ISSN | 16121872 | DOI | 10.1002/cbdv.202401152 | PubMed ID | 38771298 | Scopus ID | 2-s2.0-85197415953 |
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