Serratiochelin D, a new siderophore from Serratia marcescens

Abstract

A new siderophore, serratiochelin D (1), was isolated from a soil-derived, non-pigmented strain of Serratia marcescens along with two previously reported siderophores, serratiochelins A and B. Siderophores were obtained after cultivating the bacterium in an iron-deficient medium, and the chemical structures were elucidated based on HPLC-UV, mass spectrometry, and extensive 1D and 2D NMR spectral analyses. The iron-chelating, growth-promoting, and cytotoxic activities were evaluated using standard methods. Serratiochelin D (1) demonstrated xenosiderophoric activity by promoting the growth of Staphylococcus aureus, Acinetobacter baumannii, and Mycobacterium tuberculosis in iron-limited media and thus has the potential to be developed into a sideromycin against pathogens in these genera and other MDR bacteria.