Neurite Outgrowth-Inducing Drimane-Type Sesquiterpenoids Isolated from Cultures of the Polypore Abundisporus violaceus MUCL 56355
Sum, Winnie Chemutai; Kirchenwitz, Marco; Wanga, Lucy; Decock, Cony; Stradal, Theresia EB; Matasyoh, Josphat Clement; M{\'a}ndi, Attila; Kurt{\'a}n, Tibor; Stadler, Marc; Ebada, Sherif;
Abstract
Abundisporin A (1), together with seven previously undescribed drimane sesquiterpenes named abundisporins B-H (2-8), were isolated from a polypore, Abundisporus violaceus MUCL 56355 (Polyporaceae), collected in Kenya. Chemical structures of the isolated compounds were elucidated based on exhaustive 1D and 2D NMR spectroscopic measurements and supported by HRESIMS data. The absolute configurations of the isolated compounds were determined by using Mosher's method for 1-4 and TDDFT-ECD calculations for 4 and 5-8. None of the isolated compounds exhibited significant activities in either antimicrobial or cytotoxicity assays. Notably, all of the tested compounds demonstrated neurotrophic effects, with 1 and 6 significantly increasing outgrowth of neurites when treated with 5 ng/mL NGF.
Other data
| Title | Neurite Outgrowth-Inducing Drimane-Type Sesquiterpenoids Isolated from Cultures of the Polypore Abundisporus violaceus MUCL 56355 | Authors | Sum, Winnie Chemutai; Kirchenwitz, Marco; Wanga, Lucy; Decock, Cony; Stradal, Theresia EB; Matasyoh, Josphat Clement; M{\'a}ndi, Attila; Kurt{\'a}n, Tibor; Stadler, Marc; Ebada, Sherif | Issue Date | 24-Nov-2023 | Publisher | American Chemical Society and American Society of Pharmacognosy | Journal | Journal of Natural Products | Volume | 86 | Issue | 11 | Start page | 2457 | End page | 2467 | ISSN | 01633864 | DOI | 10.1021/acs.jnatprod.3c00525 | PubMed ID | 37910033 | Scopus ID | 2-s2.0-85176563372 |
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