Garcixanthone A, a new cytotoxic xanthone from the pericarps of Garcinia mangostana
Ibrahim, Sabrin Ragab Mohamed; Mohamed, Gamal Abdallah; Elfaky, Mahmoud Abdelkhalek; Al Haidari, Rwaida Adel; Zayed, Mohamed Fathalla; Khedr, Amgad Ibrahim Mansour; Elkholy, Amal;
Abstract
A new prenylated xanthone, garcixanthone A (5), together with eight known compounds, mangostanaxanthones I (1) and II (2), garcinone E (3), β-mangostin (4), 8-hydroxycudraxanthone G (6), garcinone C (7), cudraxanthone G (8), and (-)-epicatechin (9) were isolated from the EtOAc-soluble fraction of the air-dried pericarps of Garcinia mangostana (family Clusiaceae). Their structures were verified on the basis of spectroscopic data interpretation as well as comparison with the literature. The cytotoxic and antimicrobial activities of the new compound were assessed using sulforhodamine B (SRB) and agar disk diffusion assays, respectively. Compound 5 showed significant cytotoxic potential against epithelial lung carcinoma (A549) and breast carcinoma (MCF7) cell lines with IC 50 s 3.0 and 4.2 μM, respectively, compared to doxorubicin (0.74 and 0.41 μM, respectively).
Other data
| Title | Garcixanthone A, a new cytotoxic xanthone from the pericarps of Garcinia mangostana | Authors | Ibrahim, Sabrin Ragab Mohamed; Mohamed, Gamal Abdallah; Elfaky, Mahmoud Abdelkhalek; Al Haidari, Rwaida Adel; Zayed, Mohamed Fathalla; Khedr, Amgad Ibrahim Mansour; Elkholy, Amal | Keywords | antimicrobial | Clusiaceae | cytotoxic activity | Garcinia mangostana | garcixanthone A | xanthones | Issue Date | 2019 | Publisher | Taylor \& Francis | Journal | Journal of Asian Natural Products Research | Volume | 21 | Issue | 3 | Start page | 291 | End page | 297 | ISSN | 10286020 | DOI | 10.1080/10286020.2017.1423058 | PubMed ID | 29307236 | Scopus ID | 2-s2.0-85041118767 |
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