Disrupting the KRAS–SOS1 protein–protein interaction: mechanistic rationale for pan-KRAS pathway suppression and combination therapy

Kamel, Emadeldin M; Khadrawy, Sally Mostafa; Abukhadra, Mostafa R; Yassin, Nour YS; Alkhedhairi, Saleh; Alkhayl, Faris F Aba; Lamsabhi, Al Mokhtar; Ali, Mohamed;

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Title Disrupting the KRAS–SOS1 protein–protein interaction: mechanistic rationale for pan-KRAS pathway suppression and combination therapy
Authors Kamel, Emadeldin M; Khadrawy, Sally Mostafa; Abukhadra, Mostafa R; Yassin, Nour YS; Alkhedhairi, Saleh; Alkhayl, Faris F Aba; Lamsabhi, Al Mokhtar; Ali, Mohamed 
Issue Date 2026
Journal Frontiers in Chemistry 
Volume 14
Start page 1808601

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