Celecoxib attenuates depressive-like behavior associated with immunological liver injury in C57BL/6 mice through TNF-α and NF-κb dependent mechanisms

Baher, Walaa;

Abstract


Depression associating patients with chronic liver diseases is a major treatment goal. This study aimed to evaluate the potential hepatoprotective and antidepressant effects of celecoxib in a model of experimental autoimmune hepatitis (EAH) and depressive-like behavior in C57BL/6 mice.


Other data

Title Celecoxib attenuates depressive-like behavior associated with immunological liver injury in C57BL/6 mice through TNF-α and NF-κb dependent mechanisms
Authors Baher, Walaa 
Keywords Celecoxib; Complete Freund's adjuvant; Depressive-like behavior; EAH; NF-κB; S-100
Issue Date 2016
Journal Life sciences 
Volume 163
Start page 23
End page 37
ISSN 00243205
DOI 10.1016/j.lfs.2016.08.027
PubMed ID 27580523

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