Assessment Of Plasma Selenium Level, , 4 Glutathione Peroxidase Enzymatic Activity ; And Thyroid Functions In Patients With , •\ Phenylketonuria

Abstract

Phenylketonuria (PKU) is caused by an autosomal•recessive disorder characterized by a defect in the enzyme phenylalanine hydroxylase, which is required for converting phenylalanine to tyrosine. The symptoms of untreated PKU develop gradually, so they may not be noticed until irreversible mental retardation has occurred, hence, newborn screening is essential for prevention of these harmful effects.

Selenium is a powerful antioxidant regulating the activity of the glutathione peroxidase enzymes, which catalyse the detoxification of hydrogen peroxide and orgamc hydroperoxides.