Nanoparticles for Targeting Colon Cancer
Lydia Ramzy Adly Ramzy;
Abstract
Colorectal cancer is the third most commonly diagnosed cancer worldwide. Chemotherapeutic agents used for cancer treatment suffer from inability to specifically target cancerous tissues, without adversely affecting healthy ones. Nanoparticles can be designed in such a way to achieve cancer targeting thus, preventing premature drug release before reaching tumor tissues while simultaneously improving its internalization within cancer cells.
Colon-specific drug delivery is beneficial for the treatment of local colonic diseases including Crohn’s disease, ulcerative colitis and colorectal cancer, since it improves colonic drug concentration resulting in dose reduction and lower incidence of side effects. In our thesis, the pH-sensitive approach was adopted for achieving colon targeting. Eudragit® S100 was employed as a pH-sensitive polymer due to its dissolution behavior above pH 7.
Thymoquinone (TQ), the main ingredient of the volatile oil obtained from Nigella sativa seeds, was used as a model anticancer drug from natural source
Colon-specific drug delivery is beneficial for the treatment of local colonic diseases including Crohn’s disease, ulcerative colitis and colorectal cancer, since it improves colonic drug concentration resulting in dose reduction and lower incidence of side effects. In our thesis, the pH-sensitive approach was adopted for achieving colon targeting. Eudragit® S100 was employed as a pH-sensitive polymer due to its dissolution behavior above pH 7.
Thymoquinone (TQ), the main ingredient of the volatile oil obtained from Nigella sativa seeds, was used as a model anticancer drug from natural source
Other data
| Title | Nanoparticles for Targeting Colon Cancer | Authors | Lydia Ramzy Adly Ramzy | Issue Date | 2018 |
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