Immunohistochemical Study of Protein Gene Product 9.5and Single Strand DNA in Generalized and Segmental Vitiligo
Mohamed Hussein Hatem Abdel Rahman Abou Hadeed;
Abstract
Vitiligo is a specific type of idiopathic acquired or inherited leukoderma, which is characterized by patterned/circumscribed hypomelanosis of the skin & hair, microscopically by complete absence of melanocytes & medically by an increased risk of certain diseases, such as thyroid disease and alopecia areata.
The pathogenesis of vitiligo is contributed to many hypotheses that have been proposed to explain the destruction of melanocytes. But, three principle theories have been presented in this subject, they are the neurogenic, the self-destruct theory & the most approved hypothesis is the autoimmune theory.
The mechanisms underlying the destruction of functioning melanocytes and the absence of melanin in vitiligo lesions remain unclear. Nevertheless, certain theories have been suggested and studied including; the genetic hypothesis, the autoimmune hypothesis, the neural hypothesis (involving neuropeptides, adrenergic and cholinergic neurotransmitters), the apoptotic theory, the viral hypothesis, the self destruction hypothesis (including the significant contribution of oxidative stress through the accumulation of H2O2), and convergence theory (which combines previous theories).
This study aimed at studying the contribution of either the neural mechanism or apoptotic mechanism or both together in generalized and segmental vitiligo variants.
This study included 20 vitiligo patients (11 males and 9 females) divided into groups according to the clinical type into segmental (10 patients; 4 males and 6 females) and non segmental (10 patients; 7 males and 3 females). Their age ranged from 21-35 years with a mean of 27.2 ± 4.3 years. Twenty apparently healthy (especially dermatologically), age and sex matched healthy controls were included in the study. They were10 males and 10 females, and their age ranged from 24-45 years with a mean of 32.6 ± 6.5 years. There was no statistically significant difference between patients and controls as regards age and sex
The pathogenesis of vitiligo is contributed to many hypotheses that have been proposed to explain the destruction of melanocytes. But, three principle theories have been presented in this subject, they are the neurogenic, the self-destruct theory & the most approved hypothesis is the autoimmune theory.
The mechanisms underlying the destruction of functioning melanocytes and the absence of melanin in vitiligo lesions remain unclear. Nevertheless, certain theories have been suggested and studied including; the genetic hypothesis, the autoimmune hypothesis, the neural hypothesis (involving neuropeptides, adrenergic and cholinergic neurotransmitters), the apoptotic theory, the viral hypothesis, the self destruction hypothesis (including the significant contribution of oxidative stress through the accumulation of H2O2), and convergence theory (which combines previous theories).
This study aimed at studying the contribution of either the neural mechanism or apoptotic mechanism or both together in generalized and segmental vitiligo variants.
This study included 20 vitiligo patients (11 males and 9 females) divided into groups according to the clinical type into segmental (10 patients; 4 males and 6 females) and non segmental (10 patients; 7 males and 3 females). Their age ranged from 21-35 years with a mean of 27.2 ± 4.3 years. Twenty apparently healthy (especially dermatologically), age and sex matched healthy controls were included in the study. They were10 males and 10 females, and their age ranged from 24-45 years with a mean of 32.6 ± 6.5 years. There was no statistically significant difference between patients and controls as regards age and sex
Other data
| Title | Immunohistochemical Study of Protein Gene Product 9.5and Single Strand DNA in Generalized and Segmental Vitiligo | Other Titles | دراسة هيستوكيميائية مناعية لمنتج جين البروتين 9.5 و الحبل الواحد للحمض النووي في البهاق المعمم والقطعى | Authors | Mohamed Hussein Hatem Abdel Rahman Abou Hadeed | Issue Date | 2015 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| G10193.pdf | 268.29 kB | Adobe PDF | View/Open |
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