Effects of bariatric surgery (Sleeve Gastrectomy) on serum visfatin level and insulin resistance in obese diabetic and obese non diabetic cases

Abstract

Visfatin is a recent described adipokine that is highly expressed in visceral fat and localized to the blood stream and has various functions, including the activation of insulin receptor and has insulin mimetic effects, lowering blood glucose and improving insulin sensitivity. Bariatric surgery is an effective treatment for obesity, patients tend to lose weight rapidly after surgery, with a negative energy balance in the first few weeks. Laparoscopic Sleeve Gastrectomy is a technically less complex surgical procedure which is promising for the treatment of obesity and type 2 Diabetes Mellitus. Increased plasma visfatin levels after weight loss surgeries indicate a role for visfatin in improved insulin sensitivity, yet a decrease in serum visfatin levels after bariatric surgery induced weight reduction with no significant correlation between changes of visfatin, BMI, waist circumference, and insulin resistance, Further studies are recommended to clarify these associations. In this study we aimed at evaluation of serum levels of visfatin before and after sleeve gastrectomy surgery and their relationship with insulin resistance in obese diabetic and obese non diabetic cases.