AbstractThe potential reproductive toxicity of nonylphenol (NP) and its capability of enhancing testicular oxidative stress were assessed in adult male mice. Treatment with NP intraperitoneally for 35 days at levels 21.25 and 42.5 mg/kg b.wt. showed significant decrease in the testis and epididymus weights and reduction in sperm count and motility at the higher dose level, while the lower dose only decreased significantly the sperm motility. Both doses exhibited no effect on sperm abnormal rate, mating behaviour, fertility index and the resulted fetuses. Histologically, NP treated groups showed a significant reduction of the diameter and germinative cell layer thickness of the seminiferous tubules. NP increased the oxidative stress, indicated by significant increase in testes MDA concentrations and decrease in both GSH levels and SOD activities compared to controls.
|Keywords||Nonylphenol; Male Fertility; Oxidative stress; Mice.||Issue Date||2007||Publisher||New York : Springer-Verlag.||Source||24||Journal||Bulletin of Environmental Contamination and Toxicology||URI||http://research.asu.edu.eg/handle123456789/1234||DOI||2
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