Fetotoxicity of 2,4-dichlorophenoxyacetic acid in rats and the protective role of vitamin E

Mazhar, F.M. ; Moawad, K.M. ; El-Dakdoky, Mai H. ; Amer, A.S. 


The present study was conducted to investigate the potential role of 2,4-dichlorophenoxyacetic acid (2,4-D) in inducing developmental toxicity and oxidative damage in pregnant rats and their fetuses as well as to assess the efficacy of vitamin E to prevent or alleviate such defects. Pregnant rats received 2,4-D (100 mg/kg bw) alone or in combination with vitamin E (100 mg/kg bw) daily from gestation day 1 to 19. The number of implantations, viable and resorbed fetuses and sex ratio were not statistically different among groups. However, fetuses maternally treated with 2,4-D were characterized by lower body weight and higher morphologic and skeletal defect rate. 2,4-D induced oxidative stress in the liver of mothers and fetuses which was indicated by a significant elevation of malondialdehyde level with reduction in catalase activity and total antioxidant capacity. Coadministration of vitamin E can counteract the deleterious effects of 2,4-D by successive reduction in the oxidative stress.

Other data

Keywords 2,4-dichlorophenoxyacetic acid, fetotoxicity, oxidative stress, pregnant rats, skeletal abnormalities, vitamin E
Issue Date 2014
Publisher SAGE Publications
Source 6
Journal Toxicology and Industrial Health 
URI http://research.asu.edu.eg/handle/123456789/1255

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