Synthesis and biological screening of some chromonyl-substituted heterocycles derived from 2(3H)-furanone derivative

El-Ziaty, A.K., Abou-Elmagd, W.S.I., Ramadan, S.K., Hashem, Ahmed,

Abstract


© 2017 Taylor & Francis. A 2(3H)-furanone bearing chromonyl moiety at position-3 was synthesized and utilized for the construction of N-heterocycles such as pyrrolone, N-aminoquinolone, and pyridazinone derivatives. The reactivity of the chromonylfuranone toward some nitrogen nucleophiles such as ammonia, benzylamine, hydrazine, and phenylhydrazine was studied. On the other hand, thiation of the starting chromonylfuranone interestingly provides mono- and di-thiated products. The chemoselectivity of these reactions is discussed. The structures of all products obtained were elucidated from their analytical and spectral data. The antimicrobial activities of selected examples of the synthesized compounds were examined against two strains of bacteria and two fungus strains. Some of them showed promising antimicrobial activities.


Other data

Title Synthesis and biological screening of some chromonyl-substituted heterocycles derived from 2(3H)-furanone derivative
Authors El-Ziaty, A.K. ; Abou-Elmagd, W.S.I. ; Ramadan, S.K. ; Hashem, Ahmed 
Issue Date 2017
Publisher TAYLOR & FRANCIS INC
Journal Synthetic Communications 
URI http://research.asu.edu.eg/handle/123456789/169736
DOI 471
5
480
http://www.scopus.com/inward/record.url?eid=2-s2.0-85010664503&partnerID=MN8TOARS
47
10.1080/00397911.2016.1271896

Recommend this item
Citations 21 in scopus
Page have 6 view


Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.