Synthesis and Antitumor Activity Evaluation of Some Novel-Fused and Spiro Heterocycles Derived from a 2(3H)-Furanone Derivative

Abou-Elmagd, W.S.I. ; Hashem, Ahmed 


Abstract


© 2015 HeteroCorporation. (Chemical Equation Presented) 2(3H)-furanone 1 was fused with methyl-4-aminobenzoate followed by hydrazinolysis to give the acid hydrazide derivative 3. Treatment of 3 with carbon disulfide gave 4-amino-5-mercapto-3-substituted triazole derivative 5. The presence of mercapto and amino groups adjacent to each other in compound 5 made it valuable key precursor for the formation of fused and spiro heterocycles. Ring transformation of 5 into triazolothiadiazole and triazolothiadiazine derivatives is investigated. The antitumor and antimicrobial activities of the synthesized compounds were evaluated. Some of the tested compounds showed promising activities.


Other data

Issue Date 2016
Publisher WILEY-BLACKWELL
Journal JOURNAL OF HETEROCYCLIC CHEMISTRY 
URI http://research.asu.edu.eg/handle/123456789/169744
DOI 202
1
208
https://api.elsevier.com/content/abstract/scopus_id/84958124574
53
10.1002/jhet.2401


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