Expression Of The Apoptosis Inhibitor "Bcl-2"In Sputum Eosinophils From Children With Acute Asthma
Zeinab Mohammed El-Gabbas;
Abstract
Asthma is characterized by airway inflammation, m which eosinophils play a pivotal role. Apoptosis of eosinophils may be clinically relevant in asthma.
This study was undertaken to determine the degree of expression of the anti-apoptotic Bcl-2 protein in sputum eosinophils of children with acute asthma exacerbation and its relationship to the severity of the exacerbation.
This study was conducted on 33 asthmatic children recruited from the Pediatric Allergy and Immunology Clinic and Emergency Department of Ain Shams University Children's Hospital. They were 19 (58%) males and 14 (42%) females, their ages ranged from 5 to 15 years with a mean of
9.53±3.12 years. It also included 15 healthy children without
history of asthma or other atopic conditions and without family history of atopy as a control group. They were age and sex matched with asthmatic children.
Patients have been studied within 24 hours of the start of an acute asthma exacerbation. They were classified into 3 groups according to severity of acute asthma exacerbation (mild, moderate and severe). Each group comprised 11 patients. Severity of a cute asthma exacerbation was based on symptoms (breathlessness, talking and alertness), signs (respiratory rate, use of accessory muscles, wheeze, pulse/min and pulsus paradoxus), and functional assessment (peak expiratory flow rate, arterial blood gas analysis).
This study was undertaken to determine the degree of expression of the anti-apoptotic Bcl-2 protein in sputum eosinophils of children with acute asthma exacerbation and its relationship to the severity of the exacerbation.
This study was conducted on 33 asthmatic children recruited from the Pediatric Allergy and Immunology Clinic and Emergency Department of Ain Shams University Children's Hospital. They were 19 (58%) males and 14 (42%) females, their ages ranged from 5 to 15 years with a mean of
9.53±3.12 years. It also included 15 healthy children without
history of asthma or other atopic conditions and without family history of atopy as a control group. They were age and sex matched with asthmatic children.
Patients have been studied within 24 hours of the start of an acute asthma exacerbation. They were classified into 3 groups according to severity of acute asthma exacerbation (mild, moderate and severe). Each group comprised 11 patients. Severity of a cute asthma exacerbation was based on symptoms (breathlessness, talking and alertness), signs (respiratory rate, use of accessory muscles, wheeze, pulse/min and pulsus paradoxus), and functional assessment (peak expiratory flow rate, arterial blood gas analysis).
Other data
| Title | Expression Of The Apoptosis Inhibitor "Bcl-2"In Sputum Eosinophils From Children With Acute Asthma | Other Titles | ظهور ال(بى سى ال-2) المثبط للموت المبرمج فى الخلايا الايزينوفيلية فى بصاق الاطفال المصابين بالربو الشعبى الحاد | Authors | Zeinab Mohammed El-Gabbas | Issue Date | 2002 |
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