Effect of Adding Magnesium Sulphate to Bupivacaine in Ultra-Sound Guided Transversus abdominus Plane Block (TAP) as Post Operative Analgesia in Lower Abdominal Surgeries

Abstract

ABSTRACT The transversus abdominis plane (TAP) block is a compartment block in which the local anesthetic is distributed deep to the fascia between the internal oblique muscle and the transversus abdominis muscle. It blocks almost all of the somatic nerves that pass through abdominal structures that were cut during abdominal incision and are cause of pain generation after surgery. This method is a suitable substitute for epidural analgesia in abdominal surgeries that have a minimal visceral pain component to them. The Magnesium sulfate has been shown to have analgesic effects in animal and human models by blocking the N-methyl-D-aspartate (NMDA) receptor and associated calcium channels,thus preventing central sensitization caused by peripheral nociceptive stimulation. In addition to their central location, recent studies identified peripheral NMDA receptors in the skin, muscles, and knee joints and found that they play a role in sensory transmission of noxious signals