Plasma and tissue expression of Glutathione-S-Transferase (Gst) As A Biomarker in Ovarian Neoplasia

A H El-Shalakany, Abou Ghalia AH, N R AbdRahoh, A Khalifa ; Abou Ghalia, Azza 


Objective: To evaluate the potential clinical value of assessment of glutathione-s-transferase (GST)(total and pi fraction) in operative tissue specimens and serum (plasma) of women with ovarian neoplasia. Setting: Am Shams University Hospital for Women and Oncology Diagnostic Unit. Material & methods: Serum, plasma and operatively obtained ovarian tissue specimens from 19 women with normal ovaries (controls), 23 women with benign ovarian neoplasia and 26 women with ovarian cancer were studied. Quantitative total serum GST and plasma GST pi were determined using spectrophotometry and enzyme immunoassay respectively. Ovarian tissue samples were subjected to measurement of cytosolic GST total and pi fractions by spectrophotometry and enzyme immunoassay as well as detection of its expression by immunohistochemjcal staining in paraffin sections. Fresh ovarian tissue

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Issue Date 1999
Journal International Journal of Gynecological Cancer 

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