Comparative enhancement of curcumin cytotoxic photodynamic activity by nanoliposomes and gold nanoparticles with pharmacological appraisal in HepG2 cancer cells and Erlich solid tumor model
Fadel, Maha; Kassab, Kawser; Abd El Fadeel, Doaa A; Nasr, Maha; El Ghoubary, Nayera Mohamed;
Abstract
Curcumin is a natural pigment that generates singlet oxygen upon light excitation, hence it can be used as a photosensitizer in photodynamic therapy. The extremely low water solubility and poor systemic bioavailability make curcumin a challenging molecule to be used clinically. In this study, two nanocarrier systems for curcumin were prepared and characterized; nanoliposomes and polyvinyl pyrrolidone-capped gold nanoparticles. The dark and photocytotoxicity were investigated as a function of light fluence rate (100 and 200 mW/cm2) on HepG2 cancer cells. In vivo Erlich tumor model was developed and comparison of the tumor volume, survival rate, and histopathological alterations was made for the two nanocarriers. Results showed that both curcumin nanocarriers were successfully prepared and characterized. Light irradiation was able to augment the cytotoxicity of both curcumin liposomes and gold nanoparticles, with the former being superior in cytotoxicity compared to the latter. The tumor size was almost diminished 1 month post-photodynamic treatment for both systems with regression in the number of tumor cells upon histopathological evaluation, with curcumin liposomes producing better tumor regression than gold nanoparticles with comparable survival rate. Liposomes were confirmed to be superior to gold nanoparticles as a photodynamic treatment modality for cancer.
Other data
Title | Comparative enhancement of curcumin cytotoxic photodynamic activity by nanoliposomes and gold nanoparticles with pharmacological appraisal in HepG2 cancer cells and Erlich solid tumor model | Authors | Fadel, Maha; Kassab, Kawser; Abd El Fadeel, Doaa A; Nasr, Maha ; El Ghoubary, Nayera Mohamed | Keywords | Curcumin;cancer;gold nanoparticles;liposomes;photodynamic therapy | Issue Date | Nov-2018 | Journal | Drug development and industrial pharmacy | Volume | 44 | Issue | 11 | Start page | 1809 | End page | 1816 | ISSN | 0363-9045 1520-5762 |
DOI | 10.1080/03639045.2018.1496451 | PubMed ID | 29969300 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.