Repeated generalized seizures shortly after single intramuscular dose is an additional reasonable cause to restrict the use of ondansetron: A case report
Hanan H. Shehata; Abou Ghalia, Azza;
Abstract
Background: Ondansetron, a 5-hydroxytryptamine
(5-HT) receptor antagonist, is generally regarded as a
safe and well tolerated antiemetic. Meanwhile, some
reports mentioned that it is a probable cause of single
generalized seizures after intravenous administration.
Our report may be the first to indicate repeated generalized seizures after intramuscular therapeutic dose
of ondansetron. Methods and Results: We report a
24-year-old female with nausea and vomiting related
to gastritis that experienced repeated ondansetroninduced seizures shortly after a single intramuscular
therapeutic dose. Two minutes after intramuscular
injection of 4 mg ondansetron, our patient developed
the first generalized seizure. Within the following two
hours, seizures occurred two more times. In the
emergency department, the patient developed a fourth,
but weaker and shorter, generalized seizure. The patient was not hypoglycemic, but her blood hemoglobin and serum electrolytes were below normal. A few
hours later, the patient was discharged. The dramatic
onset of the seizures, as well as the complete recovery
and absence of any neurological sequel in our patient,
indicated that it was probably related to ondansetron.
Conclusion: Patients should be informed about the
potential side effects of ondansetron especially the lifethreatening repeated generalized seizures, and clinicians should restrict its use to hospitalized patients
(5-HT) receptor antagonist, is generally regarded as a
safe and well tolerated antiemetic. Meanwhile, some
reports mentioned that it is a probable cause of single
generalized seizures after intravenous administration.
Our report may be the first to indicate repeated generalized seizures after intramuscular therapeutic dose
of ondansetron. Methods and Results: We report a
24-year-old female with nausea and vomiting related
to gastritis that experienced repeated ondansetroninduced seizures shortly after a single intramuscular
therapeutic dose. Two minutes after intramuscular
injection of 4 mg ondansetron, our patient developed
the first generalized seizure. Within the following two
hours, seizures occurred two more times. In the
emergency department, the patient developed a fourth,
but weaker and shorter, generalized seizure. The patient was not hypoglycemic, but her blood hemoglobin and serum electrolytes were below normal. A few
hours later, the patient was discharged. The dramatic
onset of the seizures, as well as the complete recovery
and absence of any neurological sequel in our patient,
indicated that it was probably related to ondansetron.
Conclusion: Patients should be informed about the
potential side effects of ondansetron especially the lifethreatening repeated generalized seizures, and clinicians should restrict its use to hospitalized patients
Other data
Title | Repeated generalized seizures shortly after single intramuscular dose is an additional reasonable cause to restrict the use of ondansetron: A case report | Authors | Hanan H. Shehata ; Abou Ghalia, Azza | Keywords | Ondansetron; Seizures; 5-Hydroxytryptamine Receptor Antagonist | Issue Date | 2013 | Journal | Advances in Biological Chemistry | DOI | 10.4236 |
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