Expression of p53 In Relation to Different Types of Leukemias

Abstract

The explosion in the understanding of the molecular events that lead to cell proliferation has stemmed largely from the discovery that oncogenes which are genes that are involved in tumourigenesis, are highly homologies to cellular genes involved in normal growth control.

Tumour suppressor genes are genes with the, opposite action of oncogenes. They perform multiple functions in the growth, differentiations of normal cells. When these genes are inactivated by one or more mechanism of genetic abnormalities, the probability of neoplastic transformation of affected cell is enhanced.

Many known suppressor genes were identified. One of the most important of them, and the one that appears to be the most commonly altered in human malignancies, is the gene coding for a protein designated p53. Biological analysis indicated that p53 plays little part in normal cell cycle culture as a cell cycle control protein, but plays an important growth-controlling role in stressed cells. This