The protective role of Ocimum basilicum L. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like behavior
Abd-El-Ghffar, Eman A.; Al-Sayed, Eman; Shehata, Safia Mohamed; Eldahshan, Omayma A.; Efferth, Thomas;
Abstract
The gastroprotective effect of Ocimum basilicum L. (Basil) hexane extract (OBHE) in aspirin-induced gastric ulcers in mice and its ameliorative effect on behavioral alterations were determined. Pretreatment with OBHE (100 or 200 mg kg ) or misoprostol (50 μg kg ) alleviated the aspirin-induced oxidative stress by significantly decreasing (p < 0.001) gastric ulcer index scores (57, 76 and 79%), gastric TBARS (by 49, 51 and 52%), NO (21, 28 and 29%), H O (24, 42 and 45%), and the serum pro-inflammatory mediator TNF-α (21, 53 and 53%) and IL-6 (29, 30 and 31%), as well as by markedly increasing gastric GSH (41, 61 and 70%), GSH-Px (21, 32 and 34%), GST (33, 63 and 70%), GR (90, 99 and 112%), CAT (167, 211 and 267%) and serum PGE-2 levels (22, 135 and 200%) and IL-4 (64, 81 and 104%), respectively, compared with the aspirin-treated group. Meanwhile, OBHE and misoprostol induced a significant decrease (p < 0.001) in the freezing time (53, 56 and 64%), and the grooming time (by 25, 43 and 44%), respectively, compared to the aspirin treated group. This study provides evidence that OBHE confers anxiolytic, antioxidant and anti-inflammatory prophylactic effects on aspirin-induced gastric ulcers. GC/MS was used for the characterization of OBHE components. Based on the findings of this study, basil may be used as a nutritional supplement or therapeutic drug to protect against aspirin-induced gastric ulcers, a common problem resulting from the use of aspirin. -1 -1 2 2
Other data
Title | The protective role of Ocimum basilicum L. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like behavior | Authors | Abd-El-Ghffar, Eman A. ; Al-Sayed, Eman; Shehata, Safia Mohamed; Eldahshan, Omayma A.; Efferth, Thomas | Keywords | EXTRACT;GALLATE;MODELS | Issue Date | 1-Aug-2018 | Publisher | ROYAL SOC CHEMISTRY | Journal | Food & Function | Volume | 9 | Issue | 8 | Start page | 4457 | End page | 4468 | ISSN | 20426496 | DOI | 10.1039/c8fo00538a | PubMed ID | 30073231 | Scopus ID | 2-s2.0-85051967579 | Web of science ID | WOS:000449820900038 |
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