HAPTOGLOBIN GENOTYPING AND RISK OF CEREBRAL VASOSPASM AFTER ANEURYSMAL SUBARACHNOID HEMORRHAGE

Abstract

In a systematic review of population-based studies, the incidence of aneurysmal subarachnoid hemorrhage (aSAH) ranged from 2 to 16 per 100000 population. In that review, the pooled age-adjusted incidence rate of aSAH in low- to middle-income countries was found to be almost double that of high-income countries (Feigin et al., 2009). Aneurysmal subarachnoid hemorrhage is associated with greater than 35% mortality within the first 3 months. Delayed cerebral ischemia (DCI) due to cerebral vasospasm (CV) occurs in approximately one third of all patients with this disease and accounts for over 20% of its overall morbidity and mortality (Vini et al., 1997).