The Vaccines and Their Potential Impact on Antimicrobial Resistance

Abstract

Antimicrobial resistance (AMR) is now recognized as a major threat to global health. The present work aims to study the role of vaccine against AMR in broiler chickens using live avirulent multi-drug resistant E. coli vaccine also, investigate the additive effect of chitosan nanoparticles either as encapsulated or loaded form in another two live inactivated E. coli vaccine. Different samples from internal organs were collected from broiler from 10-38 day old. APEC was isolated by conventional culture methods and VITEK@ 2 COMPAT (bioMérieux, France) with prevalence ratio 67.5 %. Genes associated with virulence (iutA, fimC, and papC) were identified by PCR with the prevalence of 84.4%, 74%, and 54.8% of cases, respectively. Concerning antibiotic sensitivity test among the most resistant drugs, the highest rate of resistance was against Ampicillin (AM) (100%), Trimethoprim-Sulfamethoxazole