Preparation and characterization of silica hydrogel nanocomposites as a drug delivery system
Abu-Zeid, Hosnia;
Abstract
Nowadays, the bacterial resistant infection risks to antibiotics have the limelight of
developing new and natural antibacterial biomaterials. So, this work aimed to prepare drug
carriers for Ceftriaxone (CFX) loading based on hydrogel nanocomposites for increasing the
CFX loading capacity and improving the antibacterial properties of the hydrogels. Hence, a
novel nanocomposites based on Ca-alginate hydrogels were prepared as antibacterial model.
The morphology, textural, and the molecular interaction between the Mesoporous silica
nanoparticles (MSNs) and the hydrogels were evaluated by using SEM, DCS, and FT-IR
characterization techniques and loading efficiency was calculated. The loading efficiencies of
(0, 5, 10 % MSNs) loaded with CFX were 2.379, 19.597 and 16.05 %, respectively.
Furthermore, the antibacterial property of the hydrogels was tested by using colony forming
test at three different loaded CFX concentrations. The results showed that, as MSNs % was
increased in the alginate matrix, the loading CFX concentration increased. Thus, at 10% MSNs
of 425.6 µg/ml CFX showed a significant viability % with (p** < 0.01) that was reached to
15.473% ± 0.399 relative to negative control. So, the hydrogels were to be used as a good CFX
drug carrier and demonstrated a bactericidal effect against gram positive and gram negative
bacteria.
developing new and natural antibacterial biomaterials. So, this work aimed to prepare drug
carriers for Ceftriaxone (CFX) loading based on hydrogel nanocomposites for increasing the
CFX loading capacity and improving the antibacterial properties of the hydrogels. Hence, a
novel nanocomposites based on Ca-alginate hydrogels were prepared as antibacterial model.
The morphology, textural, and the molecular interaction between the Mesoporous silica
nanoparticles (MSNs) and the hydrogels were evaluated by using SEM, DCS, and FT-IR
characterization techniques and loading efficiency was calculated. The loading efficiencies of
(0, 5, 10 % MSNs) loaded with CFX were 2.379, 19.597 and 16.05 %, respectively.
Furthermore, the antibacterial property of the hydrogels was tested by using colony forming
test at three different loaded CFX concentrations. The results showed that, as MSNs % was
increased in the alginate matrix, the loading CFX concentration increased. Thus, at 10% MSNs
of 425.6 µg/ml CFX showed a significant viability % with (p** < 0.01) that was reached to
15.473% ± 0.399 relative to negative control. So, the hydrogels were to be used as a good CFX
drug carrier and demonstrated a bactericidal effect against gram positive and gram negative
bacteria.
Other data
Title | Preparation and characterization of silica hydrogel nanocomposites as a drug delivery system | Authors | Abu-Zeid, Hosnia | Keywords | Antibacterial;CFX;hydrogels;MSNs;nanocomposites | Issue Date | 2020 | Journal | Journal of Scientific Research in Science | Volume | 37 | Start page | 44 | End page | 60 |
Attached Files
File | Description | Size | Format | Existing users please Login |
---|---|---|---|---|
7-Preparation and characterization of silica hydrogel nanocomposites as a.pdf | 1.94 MB | Adobe PDF | Request a copy |
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.