Test, Treat, Track, Test, and Treat Active Surveillance toward Elimination of Schistosomiasis: A Feasibility Study
Abd Elaziz, Khaled; Campbell, Carl H; Kittur, Nupur; Colley, Daniel G; Haggag, Ayat A;
Abstract
We assessed the feasibility of using a test, treat, track, test, and treat (5T) active surveillance strategy to identify and treat individuals with schistosomiasis in three very low-prevalence villages in Kafr El Sheikh Governorate, Egypt. Primary index cases (PICs) were identified using the point-of-care circulating cathodic antigen (POC-CCA) assay in schools, in rural health units (retesting individuals with positive Kato-Katz examinations over the previous 6 months), and at potential water transmission sites identified by PICs and field observations. Primary cases identified potential second-generation cases-people with whom they shared water activities-who were then tracked, tested, and treated if infected. Those sharing water activities with second-generation cases were also tested. The yield of PICs from the three venues were 128 of 3,576 schoolchildren (3.6%), 42 of 696 in rural health units (6.0%), and 83 of 1,156 at water contact sites (7.2%). There were 118 second- and 19 third-generation cases identified. Persons testing positive were treated with praziquantel. Of 388 persons treated, 368 (94.8%) had posttreatment POC-CCA tests 3-4 weeks after treatment, and 81.8% (301) became negative. The 67 persons remaining positive had negative results after a second treatment. Therefore, all those found positive, treated, and followed up were negative following one or two treatments. Analysis of efforts as expressed in person-hours indicates that 4,459 person-hours were required for these 5T activities, with nearly 65% of that time spent carrying out interviews, treatments, and evaluations following treatment. The 5T strategy appears feasible and acceptable as programs move toward elimination.
Other data
Title | Test, Treat, Track, Test, and Treat Active Surveillance toward Elimination of Schistosomiasis: A Feasibility Study | Authors | Abd Elaziz, Khaled ; Campbell, Carl H; Kittur, Nupur; Colley, Daniel G; Haggag, Ayat A | Keywords | MANSONI; EGYPT | Issue Date | 2020 | Publisher | AMER SOC TROP MED & HYGIENE | Journal | American Journal of Tropical Medicine and Hygiene | Volume | 103 | Issue | 4 | Start page | 1572 | End page | 1577 | ISSN | 0002-9637 | DOI | 10.4269/ajtmh.20-0156 | PubMed ID | 32662392 | Scopus ID | 2-s2.0-85092722715 | Web of science ID | WOS:000580818500046 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.