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| Issue Date | Title | Author(s) |
| 2019 | 2-Cyano-N '-[(1,3-diphenyl-1H-pyrazol-4-yl)methylidene]acetohydrazide in the Synthesis of Nitrogen Heterocycles | Azab, ME ; Sayed K. Ramadan ; Eman A. E. El-Helw |
| 2022 | 3-Aryl/hetaryl-2-cyanoacryloyl chlorides: Synthesis and Reactions with Binucleophiles Targeting Heterocycles | El-Ziaty, Ahmed ; S.K. Ramadan ; Eman A.E. El-Helw |
| 1-Jan-2021 | Acryloyl isothiocyanate skeleton as a precursor for synthesis of some novel pyrimidine, triazole, triazepine, thiadiazolopyrimidine and acylthiourea derivatives as antioxidant agents | El-Badawy, AA; Elgubbi, AS; Eman A.E. El-Helw |
| 2014 | Antioxidant activity of heterocyclic compounds derived from 4-(4-acetamidophenyl)-4-oxobut-2-enoic acid | M. S. Salem ; El-Helw, Eman ; Dalal B. Guirguis ; Eman A. E. El-Helw ; Mosad A. Ghareeb ; Hamed A. Y. Derbala |
| 2019 | Antioxidant activity of some N-heterocycles derived from 2-(1-(2-oxo-2H-chromen-3-yl)ethylidene) hydrazinecarbothioamide | Elgubbi, AS; Eman A. E. El-Helw ; Hanan Sallam |
| 13-May-2025 | Antioxidant activity, molecular docking, and modeling pharmacokinetics study of some benzo[f]quinoline candidates | El-Fagal, Sara F; Eman A. E. El-Helw ; El-Bordany, Eman A; Ghareeb, Eman A |
| Nov-2019 | Cytotoxic and antimicrobial activities of some novel heterocycles employing 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile | Sayed K. Ramadan; Eman A. E. El-Helw ; Hanan Sallam |
| 2018 | Design and Synthesis of some N-Heterocycles Derived from Furyl-2 (3H)-Furanone | Ramadan, S. K. ; El-Helw, E. A. E. |
| 2025 | Design, synthesis, and in silico studies of pyrazolyl-thiazole and thiazolidinone hybrids as potential antiproliferative agents | Ramadan, Sayed K; Ali, Amira T; Gomha, Sobhi M; Ramadan, S.K. ; Eman A. E. El-Helw |
| 2025 | Design, Synthesis, Antiproliferative Activity and In Silico Studies of 2-Oxo-1,2-Dihydroquinolin Derivatives | Eman A. E. El-Helw ; Ghareeb, Eman A.; Mahmoud, Naglaa F. H.; El-Bordany, Eman A.; Soliman, Elsayed A.; El-Khouly, Ahmed; Abouzid, Khaled |
| 2020 | Development of Chromone-Pyrazole-Based Anticancer Agents | Salem MS, ; Derbala, HAY; Eman A. E. El-Helw ; M. S. Salem |
| 2019 | Efficient Microwave-Assisted Synthesis of Some N-Heterocycles Integrated with a Pyrazole Moiety | Sayed K. Ramadan ; Eman A. E. El-Helw |
| 1-Apr-2021 | Evaluation of some new heterocycles bearing 2-oxoquinolyl moiety as immunomodulator against highly pathogenic avian influenza virus (H5N8) | Morsy, ARI; Hashem, A.I. ; Eman A. E. El-Helw |
| 24-Apr-2026 | Exploring insecticidal activity and SAR study of newly synthesized Benzo[h]quinoline-based heterocycles against Aphis craccivora Koch. and Culex pipiens L. Larvae | Abdel-Haleem, Doaa R; Khalil, A. K. ; Sayed Karam Ramadan Emam ; Eman A. E. El-Helw |
| 1-Jan-2024 | Facile Synthesis and Antioxidant Activity Screening of Some Novel 3-Substituted Indole Derivatives | Elgubbi, Amna S.; Alzahrani, Abdullah Y.A.; Eman A. E. El-Helw ; Shaban, Safaa S. |
| 2022 | Facile Synthesis, Biological Evaluation, DFT Studies and in Silico Prediction ADME/Pharmacokinetics Properties of N-(1-(2-Chlorobenzo[h]Quinolin-3-yl)-1-Substituted-vin-2-yl)Benzamide Derivatives | Abdelrahman, AM; Fahmi, AA; Rizk, Sameh Ahmed ; Eman A. E. El-Helw |
| 2026 | Green Synthesis and Biological Assessment of Curcumin-Based Heterocycles via a Microwave-Ultrasonic-Ultraviolet Reactor: DFT, Docking, and MD Insights | Saleh, Esraa M.; Fahim, Asmaa M.; Awady, Mohamed E. El; El-Banna, Mohamed G.; Rizk, Sameh Ahmed ; Eman A. E. El-Helw |
| 2025 | In Silico ADME, DFT, and Antiproliferative Activity of Pyrazole-based Pyrimidinethione, Triazolethione, and Thiadiazolopyrimidine Derivatives | Ramadan, Sayed ; Gomha, S. M.; E.A.E. El-Helw |
| Nov-2025 | Multi-Target Rational Design and Synthesis of Some 2-Quinolinone Antitumor Candidates Downregulating the Expression of EGFR, VEGFR-2, and Telomerase With Apoptotic Potential | Eman A.E. El-Helw ; Mousa, Mai H A; Ghareeb, Eman A; Mahmoud, Naglaa F H; Sharaky, Marwa; El-Bordany, Eman A; Khatib, Arwa Omar Al; Soliman, Elsayed A; Alnajjar, Radwan; Al-Karmalawy, Ahmed A |
| 31-Dec-2026 | Multi-targeted pyrazole scaffolds: synthesis, mechanistic insights, and therapeutic potential in anticancer, antioxidant, and anti-inflammatory applications | Aljameel, Suhailah S; Eissa, Mohamed E; Alatawi, Zinab; Alahmadi, Hanadi A; Azab, Mohammad E ; Yousef, Tarek A; Aljohi, Hasan A; Al-Farraj, Eida S; Bahattab, Eman Abdullah; Ghareeb, Ahmed; El-Helw, Eman A. E. ; Sayed Karam Ramadan Emam ; Eman A. E. El-Helw |
| 2026 | Multitarget bioactive benzo [f] quinoline heterocycles from a thiocarbohydrazone scaffold: synthesis, biological assays, and in silico mechanistic rationale | Saleh, Esraa M; El-Banna, Mohamed G; Fahim, Asmaa M; El Awady, Mohamed E; Rizk, Sameh A; Eman A. E. El-Helw |
| 1-Jan-2021 | New potential fungicides pyrazole-based heterocycles derived from 2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl) acryloyl isothiocyanate | Ramadan, S.K. ; Ibrahim, NA; El-Kaed, SA; Eman A. E. El-Helw |
| 31-Jul-2018 | Proclivity of chromonyloxazolone towards some nitrogen nucleophiles | El-Helw, E. A. E. ; Derbala, Hamed A. ; El-Shahawi, Manal ; Salem, Marwa S. |
| 1-Jan-2024 | Some Thiazolopyrimidine Derivatives: Synthesis, DFT, Cytotoxicity, and Pharmacokinetics Modeling Study | Ramadan, Sayed ; Alzahrani, Abdullah Y. A.; Eman A. E. El-Helw |
| 29-Sep-2025 | Straightforward synthesis and in silico evaluation of pyrazolylthiazolidinone derivatives as prospective antiproliferative agents | Ramadan, Sayed ; Gomha, Sobhi M; El-Helw, Eman A. E. |
| Oct-2025 | Straightforward synthesis and in silico evaluation of pyrazolylthiazolidinone derivatives as prospective antiproliferative agents | Ramadan, Sayed K. ; Gomha, Sobhi M; Eman A. E. El-Helw |
| 2026 | Synthesis and In Silico Studies of New Tetrahydrobenzo[ b ]Thiophenes and Heteroannulated Candidates as Antiproliferative Agents | Elgubbi, Amna S.; Gomha, Sobhi M.; Zaki, Magdi E. A.; Sayed Karam Ramadan Emam ; Eman A. E. El-Helw |
| 2020 | Synthesis and anti-rotavirus activity of some nitrogen heterocycles integrated with pyrazole scaffold | El-Helw, EAE ; Gado, Marwa M ; El-Ziaty, Ahmed |
| 2018 | Synthesis and antimicrobial activity evaluation of some novel heterocycles derived from chromonyl-2(3H)-furanone | Ramadan, Sayed; Eman A. E. El-Helw |
| 2023 | Synthesis and Antioxidant Activity of Some Benzoquinoline-Based Heterocycles Derived from 2-((3-Chlorobenzo[f]quinolin-2-yl)methylene)hydrazine-1-carbothioamide | Asran, Mahmoud; Azab, Mohammad E.; S.K. Ramadan ; Helal, Maher H.; Eman A. E. El-Helw |
| 1-Jan-2023 | Synthesis and antioxidant activity of some pyrazole-based heterocycles using a 2(3H)-furanone building block | Youssef, Youssef M.; Elsayed, Galal A. ; El-Sayed, Amira A.; Hassaballah, Aya I.; Azab, Mohammad ; Eman A. E. El-Helw |
| 1-Jan-2021 | Synthesis and antioxidant evaluation of some heterocyclic candidates from 3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)propenonitrile | Ramadan, Sayed ; Eman A. E. El-Helw ; El-Ziaty, Ahmed |
| 2-Jul-2020 | Synthesis and antioxidant screening of new 2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl)acryloyl amide derivatives and some pyrazole-based heterocycles | Elgubbi, AS; Eman A. E. El-Helw ; Hanan Sallam |
| 1-Sep-2023 | Synthesis and antioxidant, antimicrobial, and antiviral activity of some pyrazole-based heterocycles using a 2(3H)-furanone derivative | Youssef, Youssef M.; Azab, Mohammad E. ; Elsayed, Galal A. ; El-Sayed, Amira A.; Hassaballah, Aya I.; El-Safty, Mounir M.; Soliman, Reem A.; El-Helw, EAE |
| 2022 | Synthesis and Antiproliferative Screening of Some Heterocycles Derived from 4-((5-Chloro-3-Methyl-1-Phenyl-1H-Pyrazol-4-yl)Methylene)-2-Phenyloxazol-5(4H)-One | Youssef, YM; Azab, ME; Elsayed, GA; El-Sayed, AA; Eman A. E. El-Helw |
| 2-Apr-2020 | Synthesis and antitumor activity evaluation of some pyrrolone and pyridazinone heterocycles derived from 3-((2-oxo-5-(p-tolyl)furan-3(2H)-ylidene)methyl)quinolin-2(1H)-one | Eman A.E. El-Helw ; Hashem, Ahmed |
| 1-Jan-2024 | Synthesis and Biological Applications of Coumarinyl-Chalcones | Ramadan, Sayed ; Rizk, Sameh Ahmed ; Eman A. E. El-Helw |
| 2026 | Synthesis and biological evaluation of novel heterocyclic compounds derived from ammonium thiocyanate for control of Culex pipiens and Musca domestica. | Ghareeb, Eman A; Kamal, Mahmoud; Farag, Shaimaa M; Ammar, Asmaa M; Mahmoud, Naglaa FH; Eman A. E. El-Helw |
| 12-Sep-2023 | Synthesis and cytotoxicity evaluation of novel 1,8-acridinedione derivatives bearing phthalimide moiety as potential antitumor agents | Khatab, Hassan A; Hammad, Sherif F; El-Fakharany, Esmail M; El-Helw, EAE ; Hashem, Ahmed |
| 2025 | Synthesis and Exploring Antiproliferative Activity of Some Pyrazole-Bearing Heterocycles: DFT, Molecular Docking, and ADME Study | Ramadan, Sayed ; Gomha, S. M.; El-Helw, E.A.E. |
| 1-Jan-2025 | Synthesis and In Silico Evaluation of Thiazole, Thiazolidinone, and Pyrimidinethione Candidates Bearing A Benzo[h]Quinoline Scaffold as Potential Antiproliferative Agents | Gomha, Sobhi M.; Ali, Amira T.; Sayed Karam Ramadan Emam ; Eman A. E. El-Helw |
| 5-Jul-2024 | Synthesis and in silico studies of certain benzo[f]quinoline-based heterocycles as antitumor agents | Asran, Mahmoud; Helal, Maher H; Alzahrani, Abdullah Y A; Ramadan, Sayed ; Azab, Mohammad ; Eman A. E. El-Helw |
| 2019 | Synthesis and In Vitro Antitumor Activity of Novel Chromenones Bearing Benzothiazole Moiety | Derbala, HA ; El-Shahawi, MM ; Salem MS, ; Ali, MM; Eman A. E. El-Helw ; M.M Elshahawi, Manal M. Elshahawi, Manal Mohamed El-Shahawi, Manal M. El-Shahawi ; M. S. Salem |
| 29-Nov-2025 | Synthesis and insecticidal activity of some pyrazole, pyridine, and pyrimidine candidates against Culex pipiens L. larvae | Eman A. E. El-Helw ; El-Bordany, Eman A; El-Fagal, Sara F; Ghareeb, Eman A; Doaa Ramadan Abdel Haleem Ramadan |
| 2019 | Synthesis and Reactions of 4-Oxothiazolidines: A Review | Ramadan, Sayed K; Eman A. E. El-Helw |
| 24-Mar-2025 | Synthesis of Benzo[h]quinoline derivatives and evaluation of their insecticidal activity against Culex pipiens L. larvae | Hosni, Eslam M; E.A.E. El-Helw ; Ramadan, Sayed ; Hashem, Ahmed ; Wael Abou-Elmagd |
| 2020 | Synthesis of chromenone, pyrimidinone, thiazoline, and quinolone derivatives as prospective antitumor agents | El-Badawy, AA; Eman A. E. El-Helw |
| 1-Jan-2024 | Synthesis, antiproliferative activity, and in silico studies of quinoline-based pyrimidinedione and thiazolidinedione derivatives | Alzahrani, Abdullah Y.A.; Ramadan, S.K. ; Eman A. E. El-Helw |
| 24-Nov-2025 | Synthesis, antiproliferative screening, and molecular docking of some heterocycles derived from N-(1-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-hydrazineyl-3-oxoprop-1-en-2-yl)benzamide | Eman A.E. El-Helw ; Youssef, Youssef M; Elsayed, Galal A. ; El-Sayed, Amira A; Hassaballah, Aya I; Mohamed, Ashraf M; Azab, Mohammad E |
| 14-Feb-2024 | Synthesis, computational chemical study, antiproliferative activity screening, and molecular docking of some thiophene-based oxadiazole, triazole, and thiazolidinone derivatives | Elgubbi, Amna S; Alzahrani, Abdullah Y A; Ramadan, Sayed ; Eman A.E. El-Helw |
| 2023 | Synthesis, Cytotoxic, and Antioxidant Activity of Some Benzoquinoline-Based Heterocycles | Asran, Mahmoud; Azab, Mohammad E.; Helal, Maher H.; Sayed K. Ramadan ; Eman A. E. El-Helw |
| 1-Jan-2023 | Synthesis, Density Functional Theory, Insecticidal Activity, and Molecular Docking of Some N-Heterocycles Derived from 2-((1,3-Diphenyl-1H-Pyrazol-4-yl)Methylene)Malonyl Diisothiocyanate | Abdelrahman, Aya M.; Fahmi, Abdelgawad A.; Rizk, Sameh Ahmed ; Eman A. E. El-Helw |
| 1-Jan-2023 | Synthesis, DFT and Antitumor Activity Screening of Some New Heterocycles Derived from 2,2'-(2-(1,3-Diphenyl-1H-Pyrazol-4-yl)Ethene-1,1-Diyl)Bis(4H-Benzo[d][1,3]Oxazin-4-One) | Abdelrahman, Aya M.; Fahmi, Abdelgawad A.; Rizk, Sameh Ahmed ; Eman A. E. El-Helw |
| Jul-2021 | Synthesis, DFT, and eco-friendly insecticidal activity of some N-heterocycles derived from 4-((2-oxo-1,2-dihydroquinolin-3-yl)methylene)-2-phenyloxazol-5(4H)-one | Ghareeb, Eman A; Mahmoud, Naglaa F H; El-Bordany, Eman A; El-Helw, EAE |
| 2024 | Synthesis, insecticidal Activity, and molecular docking analysis of some benzo[h]quinoline derivatives against Culex pipiens L. Larvae | Hosni, Eslam M.; Mahmoud Kamal ; Sayed Karam Ramadan Emam ; Eman A.E. El-Helw ; Hashem, Ahmed |
| 2022 | Ultrasonic Promoted Regioselective Reactions of the Novel Spiro 3,1-Benzoxazon-Isobenzofuranone Dye Toward Some Organic Base Reagents | Hassaballah, AI; S.K. Ramadan ; Abdelwahab, SS; Rizk, Sameh Ahmed ; Eman A. E. El-Helw |
| 6-Jun-2024 | β-Enaminonitrile in the synthesis of tetrahydrobenzo[b]thiophene candidates with DFT simulation, in vitro antiproliferative assessment, molecular docking, and modeling pharmacokinetics | Elgubbi, Amna S.; Abousiksaka, Motaleb S.; Alzahrani, Abdullah Y. A.; Sayed Karam Ramadan Emam ; Eman A. E. El-Helw |
