ANALYTICAL STUDY ON SOME ANTI INFLAMMATORY DRUGS

Abstract

The object of the present work is to develop simple, efficient and selective methods for the quantitative determination of the intact molecules of the three studied drugs namely, aceclofenac (AC), lomoxicam (LM) and piroxicam (PM) which can be adopted for their stability studies.

The thesis comprises four parts:

PARTI:GENERALINTRODUCTION

In this part, a brief idea about anti-inflammatory drugs, sources of drugs degradation and the theoretical background for stability indicating methods is given.

PART II: Stability indicating methods for the determination of aceclofenac

This part comprises:

1- Literature review about structure, properties, pharmacology and the reported methods for analysis of aceclofenac.

2- Experimental study, about the determination of AC in presence of its degradate using the bivariate calibration method and several chemometric methods namely classical least squares (CLS) method, principle component regression (PCR) method and partial least squares (PLS) method