The possible protective effect of stem cells on hypoxia model induced by NaNO2 on male albino rats

Abstract

Hypoxia refers to low concentrations of oxygen in the body or body parts. The condition arises from a variance between the amount of oxygen demanded by the body and the amount of oxygen in circulating blood that is supplied. Sodium nitrite (NaNO2) is a water soluble, inorganic salt widely used in various industries including agricultural, chemical industry, textile processing industry, disinfectants, coloring agents,….. etc. Humans are exposed to nitrate and nitrite beside to the previous things, also through food and drinking water, with a minor contribution from the contaminate air. It has been found to inhibit growth of microorganisms causing disease, and it is a common food additive used as a color fixative and preservative mainly in meats and fishes. So, It had a side effect on the body tissues. The body has adaptive reacts to hypoxia with acclamation responses, such as relaxation of smooth muscle, angiogenesis and vasodilatation blood vessels , thus increasing blood supply to tissues, compensating for the lack of oxygen. There are literature data mainly for the effect of sodium nitrite induced hypoxia on liver, lung, testes. But still subsequent hypoxia is poorly investigated and data about its influence on liver, lung reproductive system are controversial. The widespread use of