THYROID FUNCTIONS, SERUM ZINC AND CYTOGENETIC STUDY IN PATIENTS WITH TURNER AND KLINEFELTER SYNDROMES

Abstract

As regards Turner syndrome, the study was conducted on 21 patients, their age range was 4-38 years with a mean of 18.1 ± 9.6 years. Thyroid hormones study showed significant increase (P<O.OOI) in the serum levels of T3 with a mean of 1.61 ± 0.078 ng/mL and 0.91 ± 0.147 ng/mL for Turner syndrome and control groups respectively. However, this observed change in serum T3 level was within the normal range. The observed change in serum T3 level in this study may be due to either a circulating thyroid stimulating antibodies or an increased peripheral conversion of T4 into T3; stimulated by growth hormone or growth hormone dependent factors. This may mean that part of growth promoting factors effects in Turner syndrome patients may result from increased peripheral conversion of T4 into T3. On the other hand, no significant changes were found in serum levels of T4 and T.S.H. The serum T4 level, the mean ± S.D. were (89.42 ± 16.66 ng/mL), (91.24 ± 13.59 ng/mL) for Turner syndrome and control groups respectively (P>0.05). The T.S.H. level, the mean ± S.D. were (2.263 ± 1.0 Iu/mL), (2.256 ± 0.887 lu/mL) for Turner syndrome and control groups respectively (P>0.05). In this study two patients (9.5%) of Turner syndrome showed evidence of thyroid function disturbances. One patient had compensatory hypothyroidism and the other had euthyroid goiter.